John Patton
Assistant Professor
Department of Biomedical Engineering
(260) 665-4987 | pattonj@trine.edu
Areas of Expertise:
Drug Discovery
Tissue Engineering
Cell Adhesion
Degrees Earned:
Bachelor of Science in Chemical Engineering, University of Michigan.
Master of Science in Chemical Engineering, New Mexico State University.
Doctorate of Philosopy in Chemical Engineering, Rice University.
Work History:
Phillips Petroleum Company | 1978 - 1980
- R&D Chemical Engineer
New Mexico State University | 1980 - 1982
- Research and Teaching Assistant
Exxon Company | 1982 - 1989
- Senior Engineer
Rice University | 1989 - 1993
- Graduate Fellowship
GlycoMimetics Corporation | 1993 - 2014
- Staff Scientist (1993 - 2003)
- Director of Assays (2013 - 2014)
Trine University | 2014 - Present
- Assistant Professor
Publications:
Winkler IG, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, Magnani JL, Lévesque JP., Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance., Nat Med. 2012 Nov;18(11):1651-7.
Schwizer D, Patton JT, Cutting B, Smieško M, Wagner B, Kato A, Weckerle C, Binder FP, Rabbani S, Schwardt O, Magnani JL, Ernst B., Pre-organization of the core structure of E-selectin antagonists., Chemistry. 2012 Jan 27;18(5):1342-51.
Azab AK, Quang P, Azab F, Pitsillides C, Thompson B, Chonghaile T, Patton JT, Maiso P, Monrose V, Sacco A, Ngo HT, Flores LM, Lin CP, Magnani JL, Kung AL, Letai A, Carrasco R, Roccaro AM, Ghobrial IM., P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment., Blood. 2012 Feb 9;119(6):1468-78.
Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, Frenette PS, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood. 2010 Sep 9;116(10):1779-86.
Titz A, Patton J, Alker AM, Smiesko M, Radic Z, Schwardt O, Magnani J, Ernst B, Probing the carbohydrate recognition domain of E-selectin: The importance of the acid orientation in sLex mimetics, Bioorg Med Chem. 2010 Jan;18:19-27.
Titz A, Patton J, Alker AM, Porro M, Schwardt O, Hennig M, Francotte E, Magnani J, Ernst B, Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists?, Bioorg Med Chem. 2008 Jan 15;16(2):1046-56.
Kaila N, Somers WS, Thomas BE, Thakker P, Janz K, DeBernardo S, Tam S, Moore WJ, Yang R, Wrona W, Bedard PW, Crommie D, Keith JC Jr, Tsao DH, Alvarez JC, Ni H, Marchese E, Patton JT, Magnani JL, Camphausen RT., Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin., J Med Chem, Jun 30;48(13):4346-57., 2005.
Thoma G, Duthaler RO, Magnani JL, Patton JT., Nanomolar E-selectin inhibitors: 700-fold potentiation of affinity by multivalent ligand presentation., J Am Chem Soc., Oct 17;123(41):10113-4, 2001.
Thoma G, Banteli R, Jahnke W, Magnani JL, Patton JT., A Readily Available, Highly Potent E-Selectin Antagonist., Angew Chem Int Ed Engl., Oct 1;40(19):3644-3647, 2001.
Thoma G, Magnani JL, Patton JT, Ernst B, Jahnke W., Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin., Angew Chem Int Ed Engl. 2001 May 18;40(10):1941-1945
Thoma, G., Magnani, J.L., Patton, J.T., Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition, Bioorganic & Medicinal Chemistry Letters, 11:923-5, 2001.
Banteli R, Herold P, Burns C, Jahnke W, Patton JT, Magnani JL, Thoma G., Potent E-Selectin Antagonists., Helvetica Chimica Acta., 83:2893-2907, 2000.
Thoma G, Patton JT, Magnani JL, Ernst B, Ohrlein R, Duthaler RO., Versatile Functionalization of Polylysine: Synthesis, Characterization, and Use of Neoglycoconjugates, J Am Chem Soc., 121:5919-5929, 1999.
Thoma, G., Kinzy, W., Bruns, C., Patton, J.T., Magnani, J.L., Banteli, R., Synthesis and biological evaluation of a potent E-selectin antagonist. Journal of Medicinal Chemistry, 42:4909-4913, 1999.
Kolbinger, F., Patton, J.T., Geisenhoff, G., Aenis, A., Li, X., Katopodis, A., The carbohydrate-recognition domain of E-selectin is sufficient for ligand binding under both static and flow conditions. Biochemistry, 35:6385-6392, 1996.
Menter, D.G., Fitzgerald, L., Patton, J.T., McIntire L.V., and Nicolson, G.L., Human melanoma integrins contribute to arrest and stabilization potential while flowing over extracellular matrix. Immunology and Cell Biology, 73:575-583, 1995.
Patton, J.T., McIntire, L.V., Menter, D.G., and Nicolson, G.L., Tumor cell - substrate stabilization mediated by integrins. Materials Research Society Symposium Proceedings, 331:147-152, 1994.
Patton, J.T., Menter, D.G., Benson, D.M., McIntire, L.V., and Nicolson, G.L., Computerized analysis of flowing tumor cells to determine their adhesion stabilization lag time. Cell Motility and the Cytoskeleton, 26:88-98, 1993.
Menter, D.G., Patton, J.T., Updyke, T.V., Kerbel, R.S., Maamer, M., McIntire L.V., and Nicolson, G.L., Transglutaminase stabilizes melanoma adhesion under laminar flow. Cell Biophysics, 18: 123-143, 1992.
Patents:
Magnani, John L., Patton, Jr., John T., Sarkar, Arun K., Svarovsky, Sergei A, Ernst Beat, Heterobifunctional pan-selectin inhibitors, US 8,633,303, 2014.
Magnani, John L., Patton, Jr., John T., Williams, Leonard M., Compounds and methods for inhibiting selectin-mediated function, US 8,530,448, 2013.
Magnani, John L., Patton, Jr., John T., Smith, Theodore A. G., Treatment of cancers of the blood using selected glycomimetic compounds, US 8,518,896, 2013.
Magnani, John L, Patton, Jr., John T, Sarkar, Arun K, Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from pseudomonas, US 8,258,290, 2012.
Magnani, John L., Patton, Jr., John T., Sarkar, Arun K., Svarovsky, Sergei A., Ernst; Beat, Heterobifunctional pan-selectin inhibitors, US 7,989,601, 2011.
Magnani, John L, Patton, Jr., John T, Williams, Leonard M, Compounds and methods for inhibiting selectin-mediated function, US 7,741,312, 2010.
Magnani, John L., Patton, Jr., John T., Sarkar, Arun K., Svarovsky, Sergei A., Ernst, Beat, Heterobifunctional pan-selectin inhibitors, US 7,728,117, 2010.
Magnani, John L., Patton, Jr., John T., Sarkar, Arun K., Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas, US 7,517,980, 2009.
Magnani, John L., Patton, Jr., John T., Specific antagonist for both E- and P-selectins, US 7,361,644, 2008.
Magnani, John L., Patton, Jr., John T., Williams, Leonard M., Compounds and methods for inhibiting selectin-mediated function, US 7,060,685, 2006.
Thoma, G., Duthaler, R., Ernst, B., Magnani, J. L., Patton, J. T., Multivalent Polymers, Processes for their Preparation, and their Use for Preparing Biologically Active Compounds, US 6,677,164, 2004.
